Opportunity Information: Apply for RFA CK 22 001
The grant opportunity titled "Investigation of Monkeypox and Other Zoonotic Diseases in the Democratic Republic of the Congo (DRC)" (Funding Opportunity Number RFA CK 22 001) is a U.S. Centers for Disease Control and Prevention (CDC) cooperative agreement designed to support a focused research program in the DRC aimed at better understanding monkeypox and strengthening the country s ability to detect, investigate, and respond to it. The central goal is to study monkeypox from multiple angles at once, including its epidemiology (how it spreads among people), ecology (how it persists in nature), and anthropology (how human behavior, culture, and local practices shape transmission and reporting). The work must include at least one study site in Tshuapa Province, a region that has been important in prior monkeypox work, and it may also expand to other zoonotic diseases (diseases that spill over from animals to humans) and vaccine-preventable diseases that matter for public health in the DRC.
A major emphasis of the project is strengthening and evaluating laboratory based surveillance systems. In practical terms, this means improving the ability to identify cases quickly and accurately through better specimen collection and transport, more reliable diagnostic testing, improved data reporting workflows, and continuous quality improvement that shows whether the surveillance system is actually catching cases in real time. The NOFO also calls for field and lab investigations into viral reservoirs and the human animal interface, meaning the funded work should help clarify which animals may be maintaining the virus in the environment, how people are being exposed, and what specific contact patterns or settings increase spillover risk. This includes studying where and when human infections occur, what kinds of activities may be linked to exposure, and how ecological conditions might shape outbreaks.
Beyond detection, the opportunity supports deeper epidemiologic investigations that can map transmission chains, identify risk factors, and characterize outbreaks in ways that inform concrete public health action. It specifically highlights genome sequencing and phylogenetic analysis, signaling that the project is expected to generate and analyze viral genetic data to understand how strains are related, how the virus may be moving across places or populations, and whether distinct transmission patterns are emerging over time. Sequencing and phylogenetics can also help distinguish separate introductions from ongoing human to human spread, which is essential for tailoring response strategies.
The NOFO is not limited to describing the problem; it expects the research to lead toward solutions. That is why it explicitly includes risk mitigation and improving health communication strategies. Risk mitigation can involve identifying feasible interventions that reduce exposure at key points, such as safer practices around animal contact, infection prevention measures in healthcare settings, and community level strategies appropriate to local realities. Health communication improvements are meant to ensure messages are understandable, trusted, culturally aligned, and actionable, taking into account local beliefs and social dynamics that influence care seeking, reporting, and acceptance of interventions.
Another notable part of the scope is clinical evaluation of vaccines and therapeutic treatments. This indicates CDC is seeking evidence on how clinical countermeasures perform in the DRC context, including how they can be deployed, their acceptability, operational challenges, and potential impact on patient outcomes and transmission. The overall intention is that the project will generate evidence that can be translated into intervention planning rather than remaining purely academic.
From an administrative standpoint, this is a discretionary funding opportunity using a cooperative agreement mechanism, meaning CDC anticipates substantial involvement in the project s direction and implementation compared with a typical grant. The opportunity is offered under CFDA 93.084 through the Department of Health and Human Services, CDC. It was created on January 12, 2022, with an original application due date of April 1, 2022 by 11:59 pm Eastern Time for electronic submissions. The award ceiling is $700,000, and CDC expected to make one award, suggesting a single lead recipient coordinating a fairly comprehensive set of activities. Eligibility is listed as "Others" with clarification in the full eligibility text, implying that applicants may include certain organizations beyond the standard categories depending on the detailed criteria.
Overall, the opportunity is geared toward producing practical, evidence based strategies that the DRC Ministry of Health and other key stakeholders can use to strengthen surveillance, clarify sources and pathways of infection, improve outbreak response, and guide decisions about prevention tools like vaccines and treatments. The underlying theme is integration: linking lab systems, field investigations, genomics, social and behavioral insights, and clinical evaluation so that interventions are better targeted, more realistic to implement, and more effective in reducing illness and preventing future outbreaks.Apply for RFA CK 22 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Investigation of Monkeypox and Other Zoonotic Diseases in the Democratic Republic of the Congo (DRC)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084.
- This funding opportunity was created on Jan 12, 2022.
- Applicants must submit their applications by Apr 01, 2022 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $700,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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