Opportunity Information: Apply for PA 19 118
The Mentored Patient-Oriented Research Career Development Award (K23) is an NIH career development grant aimed at helping early-career clinician-scientists build the skills, experience, and publication record needed to become independent investigators in patient-oriented research. It is specifically meant for people who already hold a clinical doctoral degree and have made a clear commitment to conducting research that directly involves human subjects or uses human-origin materials in ways that have a direct connection to patient care and clinical outcomes. The core idea is protected, mentored time plus a structured career development plan so the awardee can grow into a competitive, independent clinical researcher.
This particular version of the K23 (PA 19-118) is tailored to applicants who will be the lead investigator of an independent clinical trial. That includes running a full clinical trial, conducting a clinical trial feasibility study (for example, to test recruitment, adherence, acceptability, or operational procedures before a larger trial), or leading an ancillary clinical trial that is separate but linked to an existing parent trial (such as adding distinct outcomes, mechanistic endpoints, or sub-studies). The key point is that the applicant is not just participating in someone else s trial for training; they are proposing to lead the trial themselves as part of the mentored award. If an applicant does not plan to lead an independent clinical trial and instead wants mentored research experience that may occur within another investigator s trial, NIH directs them to apply to a companion K23 funding announcement intended for non-independent-trial proposals.
The opportunity is offered by the National Institutes of Health and is categorized as a discretionary grant program. It spans many NIH mission areas reflected in the listed CFDA numbers (including multiple NIH institutes and centers), which signals that a wide range of patient-oriented research topics can fit as long as they align with the priorities of the institute or center to which the application is assigned. While the notice does not list a specific award ceiling or expected number of awards in the provided excerpt, K23 mechanisms generally emphasize a mentored development period with a combination of research activities and career development coursework, mentoring, and training, all organized around moving the applicant toward research independence.
A broad set of organizations can apply on behalf of an eligible candidate. Eligible applicant organizations include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses as well as small businesses), and multiple levels of government (state, county, city or township, special district), as well as independent school districts and public housing authorities or Indian housing authorities. The announcement also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), certain tribal governments and tribal organizations, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. This breadth is meant to ensure that many research settings, including those serving underserved or underrepresented populations, can host and support K23 awardees.
On the other hand, the eligibility language draws clear boundaries around non-U.S. organizations. Non-domestic (non-U.S.) entities and non-U.S. institutions are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components are allowed as defined by the NIH Grants Policy Statement, meaning a U.S.-based applicant organization can include certain international elements of the research or collaboration when justified and compliant with NIH policy.
The listing indicates an original closing date of May 12, 2020, and a creation date of December 20, 2018. That dating is important because NIH FOAs are often reissued, updated, or replaced over time, so prospective applicants typically need to confirm the current active announcement, due dates, and any policy updates before preparing an application. The essential takeaway is that PA 19-118 supports mentored clinician investigators who will personally lead an independent clinical trial (or a feasibility or ancillary trial) as the research centerpiece of a structured career development plan in patient-oriented research.Apply for PA 19 118
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.361, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.853, 93.859, 93.865, 93.866.
- This funding opportunity was created on 2018-12-20.
- Applicants must submit their applications by 2020-05-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): NIH K23 (PA 19-118) - Mentored Patient-Oriented Research Career Development Award (Independent Clinical Trial)
What is the Mentored Patient-Oriented Research Career Development Award (K23)?
The K23 is an NIH career development award designed to help early-career clinician-scientists build the skills, research experience, and publication record needed to become independent investigators in patient-oriented research. A central feature is protected, mentored time paired with a structured career development plan.
What does "patient-oriented research" mean in this opportunity?
In this context, patient-oriented research means research that directly involves human subjects, or uses human-origin materials in a way that has a direct connection to patient care and clinical outcomes.
Who is this K23 meant for?
This K23 is intended for people who already hold a clinical doctoral degree and have made a clear commitment to conducting patient-oriented research, with the goal of developing into an independent clinical researcher.
What is special about PA 19-118 compared to other K23 announcements?
PA 19-118 is specifically tailored to applicants who will be the lead investigator of an independent clinical trial as part of their mentored K23 project. The emphasis is on leading (not just participating in) the clinical trial.
Does this K23 require the applicant to lead a clinical trial?
Yes. This version of the K23 is for applicants who will lead an independent clinical trial. That can include leading a full clinical trial, leading a clinical trial feasibility study, or leading an ancillary clinical trial linked to an existing parent trial.
What kinds of clinical trial leadership are allowed under this FOA?
The announcement describes several eligible approaches, including: (1) running a full clinical trial, (2) conducting a feasibility study (for example, to test recruitment, adherence, acceptability, or operational procedures before a larger trial), or (3) leading an ancillary clinical trial that is separate but connected to a parent trial (for example, adding distinct outcomes, mechanistic endpoints, or sub-studies).
Can the research be a feasibility or pilot effort instead of a full trial?
Yes. The FOA explicitly includes clinical trial feasibility studies, such as studies focused on recruitment, adherence, acceptability, or operational procedures that support a future larger trial.
What is an ancillary clinical trial in the context of this announcement?
An ancillary clinical trial is described as a trial that is separate but linked to an existing parent trial. Examples include adding distinct outcomes, mechanistic endpoints, or related sub-studies connected to the parent trial.
Is it acceptable to be part of another investigator's clinical trial for training?
This FOA is not intended for applicants who will only gain mentored research experience within another investigator's trial without leading an independent clinical trial themselves. NIH indicates that those applicants should apply to a companion K23 funding announcement intended for non-independent-trial proposals.
If I am not planning to lead an independent clinical trial, should I apply to this FOA?
No. NIH directs applicants who are not proposing to lead an independent clinical trial (and instead plan mentored research that may occur within another investigator's trial) to apply to the companion K23 announcement intended for non-independent-trial proposals.
What is the main purpose of the K23 structure (mentoring and protected time)?
The core idea is to provide protected, mentored time plus a structured career development plan (including research activities and career development training) so the awardee can develop into a competitive, independent patient-oriented researcher.
What types of career development activities are typically part of a K23?
While the excerpt does not list specific required components, it describes K23 awards as emphasizing a mentored development period that combines research activities with career development coursework, mentoring, and training organized around moving the applicant toward research independence.
Which agency offers this grant opportunity?
This opportunity is offered by the National Institutes of Health (NIH).
How is this opportunity categorized?
It is categorized as a discretionary grant program.
What research topics are considered a fit for PA 19-118?
The opportunity spans many NIH mission areas (as reflected by multiple CFDA numbers in the listing). This suggests that a wide range of patient-oriented research topics may be responsive, as long as the project aligns with the priorities of the NIH institute or center to which the application is assigned.
Do the provided details include an award ceiling or number of awards?
No. The excerpt provided does not list a specific award ceiling or an expected number of awards.
Who applies for a K23: the individual or the organization?
Based on the eligibility language provided, organizations apply on behalf of an eligible candidate. The FOA lists a broad range of eligible applicant organization types.
What types of institutions are eligible to apply as the applicant organization?
Eligible applicant organizations include public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (including small businesses and other than small businesses); and multiple levels of government (state, county, city or township, and special district). Independent school districts and public housing authorities or Indian housing authorities are also listed as eligible.
Are minority-serving institutions explicitly included as eligible applicants?
Yes. The announcement highlights eligibility for organizations such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, and Tribally Controlled Colleges and Universities (TCCUs).
Are tribal governments and tribal organizations eligible applicant types?
Yes. The eligibility list explicitly references certain tribal governments and tribal organizations.
Can faith-based or community-based organizations apply?
Yes. Faith-based or community-based organizations are explicitly mentioned among eligible applicant types.
Are regional organizations and U.S. territories included as eligible applicants?
Yes. The eligibility list includes regional organizations and U.S. territories or possessions.
Are federal agencies eligible to apply?
Yes. The opportunity mentions eligible federal agencies among the eligible applicant types.
Are non-U.S. (foreign) organizations eligible to apply as the applicant organization?
No. Non-domestic (non-U.S.) entities and non-U.S. institutions are not eligible to apply as the applicant organization.
Can a non-domestic (non-U.S.) component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply.
Are foreign components allowed in any way?
Yes. Foreign components are allowed as defined by the NIH Grants Policy Statement. This means a U.S.-based applicant organization may include certain international elements in the research or collaboration when justified and compliant with NIH policy, even though the applicant organization itself must be U.S.-based.
What are the dates shown for this funding opportunity?
The listing indicates a creation date of December 20, 2018, and an original closing date of May 12, 2020.
Why do the dates matter for someone considering applying now?
NIH funding opportunity announcements are often reissued, updated, or replaced over time. Because the excerpt shows an original closing date in 2020, prospective applicants should confirm the currently active announcement, due dates, and any updated policies before preparing an application.
What is the key takeaway of PA 19-118?
PA 19-118 supports mentored clinician investigators in patient-oriented research who will personally lead an independent clinical trial (or a feasibility or ancillary trial) as the research centerpiece of a structured career development plan aimed at progressing toward independence.
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| Administrative Supplement for Research on Sex/Gender Influences (Admin Supp Clinical Trial Optional) Apply for PA 19 165 Funding Number: PA 19 165 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) Apply for PA 19 195 Funding Number: PA 19 195 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) Apply for PA 19 188 Funding Number: PA 19 188 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 19 191 Funding Number: PA 19 191 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 19 192 Funding Number: PA 19 192 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research on the Health of Women of Understudied, Underrepresented and Underreported (U3) Populations An ORWH FY19 Administrative Supplement (Admin Supp Clinical Trial Optional) Apply for PA 19 205 Funding Number: PA 19 205 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $140,000 |
| PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed Apply for PA 19 272 Funding Number: PA 19 272 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required Apply for PA 19 271 Funding Number: PA 19 271 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed Apply for PA 19 270 Funding Number: PA 19 270 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Emergency Competitive Revision to Existing NIH Awards (Emergency Supplement - Clinical Trial Optional) Apply for PA 20 135 Funding Number: PA 20 135 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) Apply for PA 20 166 Funding Number: PA 20 166 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required) Apply for PA 20 187 Funding Number: PA 20 187 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) Apply for PA 20 185 Funding Number: PA 20 185 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed) Apply for PA 20 188 Funding Number: PA 20 188 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required) Apply for PA 20 197 Funding Number: PA 20 197 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) Apply for PA 20 207 Funding Number: PA 20 207 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required) Apply for PA 20 206 Funding Number: PA 20 206 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed) Apply for PA 20 205 Funding Number: PA 20 205 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Not Allowed) Apply for PA 20 203 Funding Number: PA 20 203 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) Apply for PA 20 222 Funding Number: PA 20 222 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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