NIDA Program Project Grant Applications (P01 Clinical Trial Optional) | PAR 19 345

Opportunity Information: Apply for PAR 19 345

The NIDA Program Project Grant Applications (P01 Clinical Trial Optional) funding opportunity (PAR-19-345) is a National Institutes of Health grant designed to support large, collaborative research programs that bring together multidisciplinary teams to tackle high-priority topics aligned with the mission and goals of the National Institute on Drug Abuse (NIDA). The central idea behind this mechanism is synergy: NIDA is looking for a coordinated set of research activities where funding the group of projects together creates clear scientific advantages over funding the same projects separately as individual awards. In practice, that means applicants need to show that the projects are tightly linked by shared themes, complementary methods, and an integrated strategy that produces outcomes that would be difficult or impossible to achieve without the program structure.

A key structural requirement is that each proposed program must include at least three highly meritorious research projects for the full duration of the award. These projects should be organized around issues that are critical to advancing NIDA priorities, and the application should make the case that the whole is greater than the sum of its parts. Because the FOA is labeled "Clinical Trial Optional," applicants may propose projects that include clinical trials, but they are not required to do so; the mechanism is open to both clinical trial and non-clinical trial research, as long as the overall program design is compelling and scientifically integrated.

Eligibility is broad and reflects NIH's interest in supporting a diverse range of institutions and organizational types. Eligible applicants include various levels of government (state, county, city or township, and special district governments), independent school districts, public housing authorities/Indian housing authorities, and federally recognized Native American tribal governments. The opportunity is also open to higher education institutions (public/state-controlled and private), nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities, as long as they are not institutions of higher education), for-profit organizations (other than small businesses), and small businesses. In addition, the FOA explicitly calls out several categories of "other eligible applicants," including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions.

There are important constraints regarding foreign involvement. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) institutions are not eligible to apply as the applicant organization. However, non-domestic components of U.S. organizations are eligible, and foreign components (as defined under the NIH Grants Policy Statement) are allowed. This means an application must be led by an eligible U.S.-based applicant, but it can include certain international elements when they are justified and consistent with NIH policy.

Administratively, this is a discretionary grant under the NIH umbrella, listed under CFDA 93.279, and categorized in the broad area of education and health. The FOA was created on August 16, 2019, and the source data lists an original closing date of September 7, 2022 (applicants should verify the current status and any updated due dates or reissued announcements if they are planning to apply). The award ceiling and expected number of awards are not specified in the provided source details, which is common for NIH program announcements where budgets are often determined by project scope, NIH policies, and program priorities rather than a fixed published cap.

Overall, this opportunity is best suited for applicants who can assemble a strong, coordinated research program with multiple interdependent projects, demonstrate a clear plan for how the integrated effort will accelerate progress on NIDA-relevant questions, and show why the P01 structure is essential to achieving the proposed scientific impact.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NIDA Program Project Grant Applications (P01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
• This funding opportunity was created on 2019-08-16.
• Applicants must submit their applications by 2022-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 19 345

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: