Opportunity Information: Apply for RFA CE 18 006
The Centers for Disease Control and Prevention (CDC), through the National Center for Injury Prevention and Control (NCIPC), offered this R01 grant opportunity to support investigator-initiated research aimed at preventing overdose deaths linked to both prescription and illicit opioids. The central focus is on building stronger evidence about what actually works in real-world settings by either developing and piloting new interventions or rigorously evaluating promising primary or secondary prevention interventions. In this context, "interventions" is meant broadly and can include strategies, programs, or policy approaches. The larger public health purpose is to generate findings that state and local health departments can use to implement, refine, and scale efforts that reduce opioid-related fatalities.
A key theme of the opportunity is multidisciplinary, cross-sector collaboration. The CDC explicitly encourages teams that bring together expertise from fields like public health, epidemiology, social work, economics, law enforcement, and criminal justice, reflecting the reality that overdose prevention often depends on systems that extend well beyond healthcare alone. Applicants are expected to partner with community and/or governmental organizations in multiple sectors, especially those that can provide access to people at elevated risk for opioid misuse or overdose and those that can facilitate access to essential data systems. The application must show that these partnerships are already established, and it must include written agreements that spell out each partner's role in the proposed research.
The NOFO distinguishes between primary and secondary prevention and invites projects in either category. Primary prevention is framed as stopping opioid misuse, abuse, and overdose before it occurs, which could involve upstream approaches that reduce initiation, risky prescribing exposure, or progression to higher-risk use. Secondary prevention is framed as responding quickly and effectively when overdose risk is acute or after a nonfatal overdose has already happened, with examples such as emergency department-based services and structured linkage to treatment immediately following an overdose event. The intent is to support interventions that are novel or meaningfully improved and that can be tested with strong research designs, producing actionable evidence rather than purely descriptive findings.
At the same time, the CDC draws a clear boundary around what is not responsive. Studies that solely evaluate the clinical effectiveness of medications for opioid use disorder, such as buprenorphine, methadone, or naltrexone, are explicitly outside the scope for this funding announcement. In other words, the emphasis is not on medication efficacy trials, but on prevention-oriented interventions and systems-level or programmatic responses that can reduce overdose occurrence and deaths.
From an administrative and funding standpoint, this was a discretionary grant opportunity (CFDA 93.136) released by the U.S. Department of Health and Human Services, CDC. The opportunity number is RFA-CE-18-006, created March 13, 2018, with an original application due date of May 15, 2018 (with electronic submissions due by 5:00 p.m. Eastern Time). Awards were contingent on funding availability, with an anticipated seven awards and an award ceiling of $750,000. Eligibility was broad and included various levels of government (state, county, city/township, special districts), public and private institutions of higher education, federally recognized tribes and tribal organizations, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), and other eligible entities as clarified by the NOFO.
Overall, the opportunity was designed to strengthen the practical evidence base for preventing opioid overdoses by funding rigorous, collaborative research tied to implementable interventions, particularly those that can be adopted or adapted by public health agencies and cross-sector partners working with high-risk populations.Apply for RFA CE 18 006
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Research Grants for the Primary or Secondary Prevention of Opioid Overdose (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
- This funding opportunity was created on Mar 13, 2018.
- Applicants must submit their applications by May 15, 2018 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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