Opportunity Information: Apply for RFA GH 18 002
The grant opportunity, titled "Strengthening detection of emerging infectious diseases in India" (RFA GH 18 002), is a U.S. Centers for Disease Control and Prevention (CDC) cooperative agreement designed to expand and deepen work previously started under the Global Health Security Agenda (GHSA) in India. The overall intent is to improve how quickly and accurately emerging and high-impact infectious diseases are detected, understood, and acted on, with an emphasis on strengthening surveillance, diagnostics, and the links between routine public health systems and emergency response structures.
A major focus of the project is acute febrile illness (AFI), which is a common reason people are hospitalized and can be caused by many different pathogens that often look similar at first. The funding supports efforts in selected high-burden areas to identify the specific causes (etiologies) of AFI among hospitalized patients, while also examining associated risk factors and clinical outcomes. In practical terms, this means building stronger clinical and laboratory approaches that can distinguish between different infectious causes of fever, helping clinicians and public health agencies target prevention and response measures more effectively.
Another core component is generating evidence on how people seek care and use health services across selected epidemiological zones in India. By mapping health-seeking behavior and utilization patterns, the project aims to correct for undercounting that happens when surveillance data only reflect those who reach certain facilities. These data are then used to estimate the true burden of disease for key infectious causes, improving the accuracy of public health planning and allowing decision-makers to prioritize interventions based on better population-level evidence rather than incomplete facility-based snapshots.
The opportunity also emphasizes evaluating whether expanded and more advanced diagnostic testing should be implemented at district and sub-district levels, not just in centralized reference laboratories. This includes assessing both the public health impact (for example, earlier detection of outbreaks, improved case confirmation, better targeting of treatment or control measures) and the cost-effectiveness of scaling such testing. The intent is to produce actionable findings that can guide investment decisions, showing where advanced diagnostics provide clear value and where simpler approaches may be more appropriate.
In addition to generating data, the NOFO aims to strengthen the underlying systems that turn surveillance signals into coordinated action. A specific deliverable area is building models for stronger linkages to national and state emergency response mechanisms, alongside broader improvements to laboratory surveillance. This reflects an interest not only in detecting pathogens but also in ensuring that detection triggers timely communication, escalation, and response across different levels of the public health system.
Finally, the grant explicitly incorporates a One Health approach, recognizing that human health is intertwined with animal health and environmental conditions. Under this pillar, the project supports activities that strengthen cross-sector collaboration and help model disease patterns across India, which is especially relevant for emerging infections that may involve zoonotic spillover or ecological drivers. The goal is to improve the ability to anticipate and interpret disease trends by considering how pathogens move between people, animals, and environments, rather than treating human cases in isolation.
Administratively, this is a discretionary funding opportunity using a cooperative agreement mechanism, meaning the CDC would likely have substantial involvement in the project’s direction and implementation compared to a more hands-off grant. The funding opportunity was created on January 19, 2018, with an original closing date of March 20, 2018, and required electronic submission by 5:00 p.m. ET on the due date. The award ceiling listed is $3,000,000, with an expectation of a single award. The activity category is health (CFDA 93.326), and eligibility is listed broadly as "Others," with details intended to be clarified in the full eligibility section of the announcement.Apply for RFA GH 18 002
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Strengthening detection of emerging infectious diseases in India" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.326.
- This funding opportunity was created on Jan 19, 2018.
- Applicants must submit their applications by Mar 20, 2018 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $3,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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